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. 2024 Oct 9;10(20):e39149. doi: 10.1016/j.heliyon.2024.e39149

Fig. 4.

Fig. 4

Analysis of iWAT-Specific Enriched miRNAs and Shared miRNAs with iBAT. (A) Venn diagram highlighting a subset of three EV-derived miRNAs exclusively identified in iWAT. (B) KEGG enrichment analysis bubble plot for the target genes of three iWAT-specific EV-derived miRNAs, with p-values indicating the statistical significance of each pathway. (C) GO analysis of the pathways associated with the target genes of iWAT-specific EV-derived miRNAs, conducted using DAVID Bioinformatics Resources and categorized by biological process, cellular component, and molecular function, with each color representing a different category. (D) Venn diagram focusing on a subset of one EV-derived miRNA shared between iBAT and iWAT. (E) KEGG enrichment analysis bubble plot for the target genes of the shared miRNA between iBAT and iWAT, with p-values indicating the statistical significance of each pathway. (F and G) Western blot and quantification analysis of phosphorylated AKT in iWAT-derived SVF cells (n = 6 biological replicates, from three independent experiments).