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. 2024 Dec 5;19(12):e0311794. doi: 10.1371/journal.pone.0311794

Table 2. Between group baseline and week 4, 6, 8, and 12 data on primary and secondary outcome measures.

Variable Baseline (N = 48) Week 4 (RCT) (N = 48) Week 8 (IRP) (N = 48) Week 12 (IRP) (N = 47)
ITG IWLG ITG IWLG ITG IWLG ITG (N = 23) IWLG (N = 24)
M (SD) M (SD) M (SD) M (SD) d s p M (SD) M (SD) d s p M (SD) M (SD) d s p
CL-ARI+
 Temper Outbursts 0.44 (0.12) 0.46 (0.10) 0.30 (0.17) 0.42 (0.12) -0.82 .006* 0.35 (0.13) 0.33 (0.15) 0.12 .673 0.29 (0.18) 0.40 (0.12) -0.71 .019*
 Irritable Mood 0.56 (0.22) 0.48 (0.22) 0.30 (0.20) 0.53 (0.20) -1.19 <.001* 0.42 (0.28) 0.33 (0.24) -0.36 .224 0.26 (0.22) 0.45 (0.23) -0.83 .007*
 Impairment 0.365 (0.15) 0.31 (0.17) 0.15 (0.11) 0.29 (0.16) -1.01 .001* 0.20 (0.16) 0.18 (0.13) 0.18 .532 0.12 (0.12) 0.25 (0.17) -0.88 .004*
 Total 44.9 (11.3) 41.6 (11.7) 24.9 (13.8) 41.4 (12.7) -1.25 <.001* 32.2 (16.3) 27.7 (15.7) 0.29 .316 22.2 (15.4) 36.4 (13.7) -0.98 .002*
CGI-I+ 2.33 (0.76) 3.88 (0.99) 1.74 < .001* 3.17 (1.17) 2.79 (1.10) 0.33 .258 2.39 (0.78) 3.64 (1.17) -1.23 <.001*
CGI-S 3.96 (0.55) 4.00 (0.65) 2.92 (1.02) 3.92 (0.66) -1.17 < .001* 3.42 (0.88) 3.38 (0.77) 0.05 .862 2.88 (1.08) 3.83 (0.76) -1.03 <.001*
CGAS 55.1 (6.33) 55.3 (6.55) 64.2 (9.50) 55.8 (7.09) 1.00 .001* 60.2 (8.92) 61.0 (8.09) -0.10 .736 65.1 (9.11) 57.4 (7.62) 0.92 .003*
PTP 3.21 (1.32) 4.71 (0.91) -1.33 < .001* 4.08 (1.41) 3.63 (1.28) 0.34 .245 3.13 (1.25) 4.38 (1.17) -1.03 .001*
ARI 8.38 (1.84) 8.38 (2.02) 3.67 (2.32) 7.08 (2.0) -1.58 < .001* 5.75 (2.98) 4.83 (3.02) 0.31 .295 3.30 (2.34) 5.79 (3.11) -0.90 .003*
SDQ
 Externalising Score 11.0 (2.77) 11.7 (4.33) 8.85 (2.95) 11.6 (4.07) -0.84 .006* 9.29 (3.32) 9.79 (4.80) -0.121 .677 7.96 (3.46) 10.33 (4.34) -0.60 .044*
 Internalising Score 5.88 (3.13) 6.96 (4.14) 3.58 (2.55) 7.08 (3.46) -1.15 < .001* 4.42 (3.73) 5.42 (3.17) -0.29 .323 2.87 (2.75) 6.04 (3.78) -0.10 .002*
 Total Difficulties Score 16.6 (3.93) 18.6 (7.13) 12.2 (4.1) 18.7 (5.89) -1.28 < .001* 13.71 (5.19) 15.21 (6.55) -0.254 .384 10.83 (4.67) 16.38 (6.76) -0.95 .002*
 Impact Score 3.63 (1.66) 3.92 (1.91) 2.21 (1.59) 3.25 (2.21) -0.54 .068 2.42 (1.38) 2.83 (2.41) -0.212 .467 1.26 (1.52) 3.38 (2.83) -0.93 .003*
SNAP-IV
 ADHD 29.6 (10.2) 33.0 (12.5) 22.6 (11.1) 29.3 (13.1) -0.55 .062 24.2 (11.7) 26.9 (13.3) -0.21 .465 22.1 (10.5) 29.8 (14.8) -0.60 .046*
 ODD 15.5 (4.88) 15.1 (4.74) 10.0 (4.74) 13.6 (4.11) -0.82 .007* 11.0 (5.20) 11.50 (5.73) -0.08 .773 9.04 (5.60) 12.7 (5.30) -0.66 .027*
EBQ 34.8 (5.47) 34.4 (5.95) 35.7 (4.85) 34.3 (5.70) 0.27 .059 34.9 (5.73) 34.1 (5.33) 0.14 .641 35.0 (5.70) 34.4 (5.72) 0.10 .728
DASS-21
 Depression 4.67 (5.49) 7.08 (6.49) 3.83 (3.82) 4.17 (5.17) -0.07 .800 2.92 (2.83) 4.75 (7.39) -0.33 .265 2.26 (2.12) 5.67 (6.15) -0.74 .016*
 Anxiety 2.58 (2.73) 4.42 (5.66) 1.83 (2.76) 3.00 (4.04) -0.34 .250 2.00 (2.57) 2.75 (3.58) -0.24 .409 1.83 (2.82) 3.17 (3.77) -0.40 .174
 Stress 13.50 (7.42) 14.50 (6.76) 9.25 (5.59) 11.25 (6.97) -0.32 .279 10.83 (6.40) 10.17 (6.27) 0.11 .717 10.00 (6.06) 13.42 (9.06) -0.44 .138

Note. M = mean; SD = standard deviation, d = Cohen’s d effect size; RCT = randomized control trial phase; IRP = immediate replication phase; CL-ARI = Revised Clinician-rated Affective Reactivity Scale; CGI-I = Clinical Global Impressions Improvement Scale; PTP = Parent Target Problem Rating Scale; ARI = Affective Reactivity Index; SDQ = Strengths and Difficulties Questionnaire; SNAP-IV = The Child Swanson, Nolan, and Pelham-IV Questionnaire 26; EBQ = Eating Behavior Questionnaire.

+ = primary measure.

* p < .05.