Fig 2.

Efficacy of different drugs or regimens against M. tuberculosis in an active TB disease model after 1 month (4 weeks) of treatment in experiment 2. Nine mice (three from each infection run) were humanely sacrificed one day after infection (D-14) and on the day of treatment initiation (D0) to assess lung CFU counts, respectively. The experimental group of mice received either monotherapy, dual medication, or a regimen for 1 month before CFU detection at sacrifice. Abbreviations and doses (mg/kg): B, bedaquiline, 25; Pa, pretomanid, 100; L, linezolid, 100; S, sudapyridine, 25; C, clofazimine, 25; T, TB47, 25; and Z, pyrazinamide, 150. All the drugs were administered orally once a day, 5 days per week. Values are means ± SD; n = 5. ns, not significant; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.