TABLE 3.

Lung CFU counts and proportions of mice relapsed after treatment completion in experiment 2^e

Regimena	Mean (±SD) lung log10 CFUb					Proportion of mice with culture-positive lungs after treatmentc
	D-14	D0	M1	M1.5	M2	M1.5	M2	M2.5
Untreated	4.09 ± 0.10	7.58 ± 0.15
BPaL			3.43 ± 0.26	1.55 ± 0.39	0.98 ± 0.61e1		10/15	4/15
S			4.84 ± 0.34
C			5.55 ± 0.04d
T			7.66 ± 0.39
SC			3.62 ± 0.57
ST			4.65 ± 0.31
CT			4.06 ± 0.43
SCT			3.20 ± 0.29	1.97 ± 0.15	0.71 ± 0.69e2		5/15	2/15
SCTL			2.78 ± 0.49	2.07 ± 0.18	0.46 ± 0.65e3	15/15	7/15	0/15
SCL			3.47 ± 0.51	2.84 ± 0.35	1.83 ± 0.50		14/15
STL			4.55 ± 0.36	3.59 ± 0.40	2.88 ± 0.47		15/15	15/15
SCZ			1.97 ± 0.15	1.12 ± 0.71e1	0.24 ± 0.54e4		0/15
SCTZ			1.99 ± 0.27	1.43 ± 0.29	0.34 ± 0.49e3	1/15	0/15	0/15

^a Abbreviations and doses (mg/kg): B, bedaquiline, 25; Pa, pretomanid, 100; L, linezolid, 100; S, sudapyridine, 25; C, clofazimine, 25; T, TB47, 25; and Z, pyrazinamide, 150. All the drugs were administered orally once a day, 5 days per week.

^b Time points are shown as days (D-14 or D0) or months (M) of treatment. D-14, 1 day after aerosol infection with M. tuberculosis H37Rv; D0, day of treatment initiation; M1, 1 month (4 weeks) after treatment initiation, and so on.

^c Upon completing the prescribed course of treatment, 15 mice were designated for relapse assessment at each time point, as indicated by the proportions in the table. The mice were held for 4 additional months after treatment completion.

^d Only two out of five mice had survived until this time point.

^e en, N out of 5 mice showed 0 lung CFU. For example, e3 means three out of five mice were culture negative.