Supplemental Table 2. Hazard ratios for composite events by SPP and ABI tertiles in all patients.
| Tertile | SPP | ABI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adjusted for 8 factors | Adjusted for 20 factors | Adjusted for 8 factors | Adjusted for 20 factors | |||||||||
| HR | 95％ CI | p value | HR | 95％ CI | p value | HR | 95％ CI | p value | HR | 95％ CI | p value | |
| T1 | 2.58 | (1.57, 4.23) | ＜0.001 | 2.82 | (1.62, 4.92) | ＜0.001 | 1.70 | (1.06, 2.74) | 0.028 | 1.65 | (1.00, 2.74) | 0.052 |
| T2 | 1.50 | (0.89, 2.54) | 0.129 | 1.56 | (0.89, 2.73) | 0.122 | 1.36 | (0.82, 2.25) | 0.240 | 1.36 | (0.80, 2.31) | 0.253 |
| T3 | ref. | ref. | ref. | ref. | ||||||||
| Age | 1.03 | (1.01, 1.04) | 0.003 | 1.02 | (1.00, 1.04) | 0.069 | 1.03 | (1.01, 1.05) | 0.003 | 1.02 | (1.00, 1.04) | 0.059 |
| Male sex | 1.26 | (0.82, 1.92) | 0.289 | 1.40 | (0.76, 2.57) | 0.281 | 1.32 | (0.85, 2.04) | 0.217 | 1.53 | (0.82, 2.85) | 0.180 |
| Body mass index | 0.96 | (0.89, 1.03) | 0.212 | 0.97 | (0.91, 1.04) | 0.428 | ||||||
| Activities of Daily Living | 1.08 | (0.74, 1.58) | 0.707 | 1.18 | (0.81, 1.73) | 0.389 | ||||||
| Current smoking | 1.03 | (0.55, 1.94) | 0.932 | 1.23 | (0.67, 2.27) | 0.505 | ||||||
| Systolic blood pressure | 1.00 | (1.00, 1.01) | 0.436 | 1.00 | (0.99, 1.01) | 0.736 | 1.00 | (0.99, 1.01) | 0.776 | 1.00 | (0.99, 1.01) | 0.854 |
| Prior history of AVE | 1.16 | (0.79, 1.72) | 0.443 | 1.08 | (0.71, 1.67) | 0.715 | 1.20 | (0.81, 1.78) | 0.367 | 1.10 | (0.72, 1.70) | 0.653 |
| Diabetes mellitus | 1.20 | (0.81, 1.77) | 0.36 | 1.30 | (0.82, 2.06) | 0.266 | 1.14 | (0.77, 1.69) | 0.506 | 1.27 | (0.82, 1.99) | 0.287 |
| Albumin | 0.41 | (0.25, 0.66) | ＜0.001 | 0.41 | (0.24, 0.70) | 0.001 | 0.43 | (0.27, 0.70) | 0.001 | 0.44 | (0.26, 0.74) | 0.002 |
| C-reactive protein | 1.09 | (0.96, 1.24) | 0.169 | 1.15 | (0.99, 1.33) | 0.077 | 1.12 | (0.99, 1.26) | 0.064 | 1.13 | (0.97, 1.31) | 0.123 |
| Hemoglobin | 0.78 | (0.62, 0.99) | 0.044 | 0.72 | (0.54, 0.95) | 0.020 | 0.76 | (0.60, 0.96) | 0.022 | 0.72 | (0.55, 0.95) | 0.019 |
| Erythropoietin resistance index | 0.99 | (0.97, 1.02) | 0.671 | 1.00 | (0.97, 1.03) | 0.886 | ||||||
| Calcium-phosphate product | 1.01 | (0.99, 1.03) | 0.222 | 1.00 | (0.99, 1.02) | 0.702 | ||||||
| Intact parathyroid hormone | 1.00 | (1.00, 1.00) | 0.850 | 1.00 | (1.00, 1.00) | 0.936 | ||||||
| Antihypertensive drugs | 1.06 | (0.66, 1.70) | 0.814 | 0.90 | (0.57, 1.43) | 0.651 | ||||||
| Antilipemic drugs | 1.11 | (0.65, 1.89) | 0.708 | 1.11 | (0.64, 1.91) | 0.714 | ||||||
| Calcium-containing phosphate binders | 0.9 | (0.49, 1.63) | 0.721 | 0.87 | (0.50, 1.51) | 0.618 | ||||||
| Dialysis time per session | 1.00 | (0.98, 1.01) | 0.699 | 1.00 | (0.98, 1.02) | 0.716 | ||||||
| Quantity of blood flow in treatment | 1.00 | (0.99, 1.02) | 0.643 | 1.00 | (0.99, 1.02) | 0.669 | ||||||
| Single pool Kt/V urea nitrogen | 1.40 | (0.30, 6.56) | 0.666 | 1.62 | (0.37, 6.99) | 0.520 | ||||||
Cox proportional hazard models were adjusted for 20 literature-based covariates: age, sex, body mass index, activities of daily living, current smoking, systolic blood pressure, prior history of AVE and diabetes, laboratory data of albumin, C-reactive protein, hemoglobin, calcium-phosphate product, intact parathyroid hormone, erythropoietin resistance index, single-pool Kt/V urea nitrogen, medication status of antihypertensive drugs, antilipemic drugs, calcium-containing phosphate binders, dialysis prescription of therapy time per session, and quantity of blood flow per minute. Of these 20 factors, we selected eight confounders for assessing model performance (Table 3) or other statistical analyses. We confirmed that the HRs were consistent across models, adjusting for 8 or all 20 variables.
SPP, skin perfusion pressure; ABI, ankle-brachial index; HR, hazard ratio; CI, confidence interval; T1, 1st tertile; T2, 2nd tertile; T3, 3rd tertile; AVE, atherosclerotic vascular event.