Supplemental Table 3. Baseline characteristics of patients with normal ABIs in a subgroup analysis.
| Characteristics | Overall N = 215 | SPP T1 n =74 | SPP T2 + T3 n =141 | p value |
|---|---|---|---|---|
| SPP, mmHg | 76.4 (16.5) | 58.9 (9.8) | 85.6 (10.9) | ＜0.001＊ |
| Age, years | 70.1 (60.8, 76.0) | 73.6 (61.6, 79.2) | 67.6 (60.6, 73.2) | 0.004＊ |
| Male sex, n (%) | 138 (64.2%) | 51 (68.9%) | 87 (61.7%) | 0.290 |
| Duration of dialysis, years | 1.6 (0.1, 5.4) | 1.9 (0.2, 5.7) | 1.2 (0.1, 5.0) | 0.250 |
| Body mass index, kg/m² | 21.9 (19.7, 24.6) | 21.6 (19.4, 25.0) | 22.1 (20.0, 24.4) | 0.690 |
| Systolic blood pressure, mmHg | 157 (24) | 152 (26) | 160 (22) | 0.028＊ |
| Current smoking, n (%) | 29 (13.5%) | 10 (13.5%) | 19 (13.5%) | 0.990 |
| Prior history of | ||||
| Any AVE, n (%) | 59 (27.4%) | 28 (37.8%) | 31 (22.0%) | 0.013＊ |
| CAD, n (%) | 22 (10.2%) | 13 (17.6%) | 9 (6.4%) | 0.010＊ |
| Stroke, n (%) | 42 (19.5%) | 17 (23.0%) | 25 (17.7%) | 0.360 |
| Comorbidities | ||||
| Diabetes mellitus, n (%) | 96 (44.7%) | 40 (54.1%) | 56 (39.7%) | 0.045＊ |
| Hypertension, n (%) | 145 (67.4%) | 44 (59.5%) | 101 (71.6%) | 0.070 |
| Laboratory data | ||||
| Urea nitrogen, mg/dL | 59.9 (13.9) | 58.9 (13.5) | 60.4 (14.1) | 0.450 |
| Creatinine, mg/dL | 9.7 (2.7) | 9.6 (2.5) | 9.8 (2.8) | 0.590 |
| Albumin, g/dL | 3.7 (3.4, 4.0) | 3.7 (3.4, 4.0) | 3.7 (3.5, 3.9) | 0.900 |
| C-reactive protein | 0.12 (0.05, 0.41) | 0.13 (0.07, 0.43) | 0.08 (0.04, 0.40) | 0.066 |
| Albumin-adjusted Ca, mg/dL | 9.0 (0.6) | 9.0 (0.7) | 8.9 (0.6) | 0.450 |
| Phosphate, mg/dL | 5.0 (1.3) | 4.9 (1.3) | 5.1 (1.3) | 0.370 |
| Intact PTH, pg/mL | 206 (129, 296) | 207 (118, 274) | 206 (132, 300) | 0.530 |
| Hemoglobin, g/dL | 10.5 (0.8) | 10.4 (0.8) | 10.5 (0.8) | 0.430 |
| Total cholesterol, mg/dL | 156 (135, 179) | 144 (130, 161) | 163 (144, 190) | ＜0.001＊ |
| HDL cholesterol, mg/dL | 49 (40, 61) | 44 (39, 56) | 53 (40, 65) | 0.020＊ |
In patients with normal ABI levels, the cut-off points of SPP tertiles were 71 and 83 mmHg. Because those with SPP T1 had a significantly higher event rate, the patients’ background characteristics were compared with those of SPP T1 with T2+T3. Differences were assessed using the unpaired Student’s t-test, Mann–Whitney test, or chi-square test, as needed. ＊denotes a significance level of p＜0.05.
ABI, ankle-brachial index; T1, 1st tertile; T2, 2nd tertile; T3, 3rd tertile; N, number of all patients; n, number of patients in a specific group; SPP, skin perfusion pressure; AVE, atherosclerotic vascular event; CAD, coronary artery disease; Ca, calcium; PTH, parathyroid hormone; HDL, high- density lipoprotein.