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. 2024 Nov 22;11:1470833. doi: 10.3389/fnut.2024.1470833

Table 5.

The combined effect of CDAI and eczema on the odds of depression in subgroups.

Subgroups Outcome/Total Unadjusted Model 1
OR (95% CI) P OR (95% CI) P
Gender = Female n = 98/1752
CDAI and Eczema
Eczema = No and CDAI=High n = 13/303 Ref Ref
Eczema = No and CDAI = Low n = 72/1326 2.12 (0.89–5.07) 0.117 1.94 (0.74–5.05) 0.248
Eczema = Yes and CDAI=High n = 1/26 0.94 (0.12–7.57) 0.954 1.80 (0.25–12.70) 0.588
Eczema = Yes and CDAI = Low n = 12/97 5.37 (2.14–13.46) 0.004 6.06 (2.28–16.13) 0.023
P for trend 0.003 P for trend 0.022
RERI 3.31 (−1.42–8.05) 3.33 (−3.09–9.74)
AP 0.62 (0.09–1.15) 0.55 (−0.17–1.27)
SI 4.13 (0.31–54.29) 2.92 (0.27–32.13)
Gender = Male n = 76/1650
CDAI and Eczema
Eczema = No and CDAI=High n = 14/485 Ref Ref
Eczema = No and CDAI = Low n = 52/1076 2.30 (1.24–4.29) 0.022 1.85 (0.93–3.72) 0.157
Eczema = Yes and CDAI=High n = 3/37 1.95 (0.72–5.24) 0.213 2.42 (0.91–6.41) 0.151
Eczema = Yes and CDAI = Low n = 7/52 8.35 (3.48–20.02) <0.001 9.61 (3.36–27.52) 0.013
P for trend <0.001 P for trend 0.014
RERI 5.10 (−1.24–11.45) 6.34 (−3.11–15.79)
AP 0.61 (0.27–0.95) 0.66 (0.27–1.05)
SI 3.27 (1.03–10.34) 3.79 (0.89–16.09)
BMI < 25 n = 51/1024
CDAI and Eczema
Eczema = No and CDAI=High n = 9/231 Ref Ref
Eczema = No and CDAI = Low n = 36/718 1.95 (0.80–4.76) 0.167 1.75 (0.73–4.21) 0.276
Eczema = Yes and CDAI=High n = 1/22 0.92 (0.13–6.64) 0.934 1.36 (0.18–10.43) 0.784
Eczema = Yes and CDAI = Low n = 5/53 5.77 (2.20–15.14) 0.004 6.41 (2.34–17.55) 0.022
P for trend 0.005 P for trend 0.023
RERI 3.90 (−1.37–9.17) 4.30 (−1.72–10.32)
AP 0.68 (0.21–1.14) 0.67 (0.18–1.16)
SI 5.48 (0.29–102.92) 4.87 (0.32–74.43)
BMI ≥ 25 n = 123/2378
CDAI and Eczema
Eczema = No and CDAI=High n = 18/557 Ref Ref
Eczema = No and CDAI = Low n = 88/1684 2.36 (1.32–4.20) 0.013 1.85 (0.97–3.53) 0.135
Eczema = Yes and CDAI=High n = 3/41 1.95 (0.76–5.01) 0.192 2.45 (0.94–6.36) 0.140
Eczema = Yes and CDAI = Low n = 14/96 6.65 (3.21–13.75) <0.001 7.54 (3.58–15.88) 0.006
P for trend <0.001 P for trend 0.007
RERI 3.34 (−1.76–8.45) 4.24 (−1.94–10.42)
AP 0.50 (0.00–1.00) 0.56 (0.06–1.07)
SI 2.45 (0.64–9.45) 2.84 (0.61–13.24)
Smoking = No n = 64/1808
CDAI and Eczema
Eczema = No and CDAI=High n = 10/412 Ref Ref
Eczema = No and CDAI = Low n = 46/1282 2.10 (0.91–4.83) 0.107 1.77 (0.72–4.35) 0.268
Eczema = Yes and CDAI=High n = 1/34 1.29 (0.16–10.34) 0.816 1.53 (0.18–12.78) 0.709
Eczema = Yes and CDAI = Low n = 7/80 7.46 (2.40–23.17) 0.005 9.93 (2.88–34.25) 0.015
P for trend 0.003 P for trend 0.014
RERI 5.07 (−2.81–12.95) 7.63 (−3.71–18.96)
AP 0.68 (0.18–1.18) 0.77 (0.36–1.17)
SI 4.66 (0.37–58.12) 6.85 (0.36–131.66)
Smoking = Yes n = 110/1594
CDAI and Eczema
Eczema = No and CDAI=High n = 17/376 Ref Ref
Eczema = No and CDAI = Low n = 78/1120 2.36 (1.27–4.36) 0.018 1.87 (1.01–3.44) 0.103
Eczema = Yes and CDAI=High n = 3/29 1.64 (0.66–4.03) 0.305 2.51 (1.13–5.57) 0.073
Eczema = Yes and CDAI = Low n = 12/69 6.33 (3.31–12.10) <0.001 6.62 (3.82–11.46) 0.001
P for trend <0.001 P for trend 0.001
RERI 3.33 (0.17–6.49) 3.24 (−0.31–6.79)
AP 0.53 (0.22–0.84) 0.49 (0.12–0.86)
SI 2.67 (1.02–7.00) 2.37 (0.88–6.38)

OR, hazard ratio; CI, confidence intervals; Ref, reference; CDAI, composite dietary antioxidant index; Model 1 adjusting race, PIR, marriage, education, sleep duration, smoking, house smoker, hypertension, diabetes, CVD, and serum Vitamin D.