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. 2024 Oct 31;21(12):2271–2286. doi: 10.1038/s41592-024-02471-8

Overview of VeloCycle latent variables

Variable Description General name Training step Dimensions
φxy cell cycle phase Manifold coordinates manifold learning (cell)
ν Fourier coefficients for the genes Manifold geometry manifold learning (gene, harmonics)
Δν batch-specific expression offset Data-specific noise in manifold geometry manifold learning (batch, gene)
shape_inv spliced NB noise Measurement noise manifold learning (gene)
logβg log splicing rate Velocity kinetics velocity learning (gene)
logγg log degradation rate Velocity kinetics velocity learning (gene)
νω Fourier coefficients for the angular speed Velocity function velocity learning (condition, harmonics)