Figure 7.

The protective efficacy of LT33 and LT28 challenged with the H37Rv strain. At 12 weeks after the last immunization, the C57BL/6 mice were aerosol-infected with the M. tuberculosis H37Rv strain. Survival curves of C57BL/6 mice infected with M. tuberculosis H37Rv (A). Mice were euthanized and the bacterial burden (H37Rv) was measured in the lungs (B). Mice were euthanized and the bacterial burden (H37Rv) was measured in the spleen (C). All data were shown as means ± SD, n = 3–6. Three mice in DPC groups were used in the quality control for infection. *p < 0.05; **p < 0.01.