Table 3.
The production of antigen-specific IgG, IgG1, and IgG2c induced by LT28.
| Groups | Antibody titers | ||||
|---|---|---|---|---|---|
| IgG | IgG1 | IgG2c | IgG2c/IgG1 | ||
| PBS | – | – | – | – | |
| BCG | – | – | – | – | |
| Anti-MPT64 | MPT64 | 5.44 ± 0.51 | 4.85 ± 0.15 | 4.93 ± 0.05 | 1.016 |
| LT28 | 4.82 ± 0.14 | 4.53 ± 0.20 | 4.70 ± 0.29 | 1.037 | |
| Anti-Rv1978 | Rv1978 | 4.88 ± 0.65 | 4.35 ± 0.15 | 3.92 ± 0.11 | 0.901 |
| LT28 | 4.55 ± 0.33 | 3.58 ± 0.08 | 4.33 ± 0.39 | 1.209 | |
| Anti-Rv2645 | LT28 | 4.52 ± 0.27 | 4.30 ± 0.02 | 4.16 ± 0.37 | 0.967 |
At 12 weeks after the last immunization, the IgG, IgG1, and IgG2c against MPT64, Rv1978, and Rv2645 (peptide) in serum were measured by ELISA. Data are expressed as means ± standard deviation (SD) (n = 4). Antibody titers are presented as the means of log10 antibody titers ± SD.