Table 1.
Characteristics of carbapenemase-producing K. pneumoniae or E. coli causing colonization or infection. Data are number of isolates (percentage)
| All cases (n = 386) | Colonization (n = 90) | Infection (n = 296) | P value | |
|---|---|---|---|---|
| Microorganism | ||||
| K. pneumoniae | 363 (94.0) | 83 (92.2) | 280 (94.6) | 0.40 |
| E. coli | 23 (6.0) | 7 (7.8) | 16 (5.4) | |
| Sequence type (K. pneumoniae) | ||||
| ST11 | 67 (17.4) | 16 (17.8) | 51 (17.2) | 0.82 |
| ST15 | 47 (12.2) | 15 (16.7) | 32 (10.8) | 0.08 |
| ST147 | 36 (9.3) | 14 (15.6) | 22 (7.4) | 0.01 |
| ST307 | 77 (19.9) | 16 (17.8) | 61 (20.6) | 0.62 |
| ST392 | 15 (3.9) | 7 (7.8) | 8 (2.7) | 0.02 |
| ST258/512 | 49 (23.3) | 8 (9.6) | 41 (14.6) | 0.24 |
| Carbapenemase typea | ||||
| OXA-48-like | 276 (71.5) | 67 (74.4) | 209 (70.6) | 0.48 |
| KPC | 71 (18.4) | 17 (18.9) | 54 (18.2) | 0.89 |
| Metallo-β-lactamases | 43 (11.1) | 9 (10.0) | 34 (11.4) | 0.69 |
| Antimicrobial resistance | ||||
| Ceftazidime | 319 (82.6) | 74 (82.2) | 245 (82.8) | 0.43 |
| Meropenem | 104 (26.9) | 27 (30.0) | 77 (26.0) | 0.45 |
| Aztreonam | 309 (80.1) | 75 (83.3) | 234 (79.1) | 0.37 |
| Ceftazidime/avibactam | 98 (25.4) | 20 (22.2) | 78 (26.4) | 0.43 |
| Meropenem/vaborbactam | 39 (10.1) | 15 (16.7) | 24 (8.1) | 0.01 |
| Imipenem/relebactam | 84 (21.8) | 22 (24.4) | 62 (20.9) | 0.48 |
| Cefiderocol | 11 (2–8) | 2 (2.2) | 9 (3.0) | 0.68 |
| Gentamicin | 179 (46.4) | 46 (41.1) | 133 (44.9) | 0.30 |
| Tobramycin | 272 (70.5) | 66 (73.3) | 206 (69.6) | 0.46 |
| Amikacin | 72 (18.7) | 21 (23.3) | 51 (17.2) | 0.19 |
| Plazomicin | 23 (6.0) | 14 (15.6) | 9 (3.0) | < 0.001 |
| Tigecycline | 24 (6.4) | 5 (5.6) | 19 (6.4) | 0.90 |
| Ciprofloxacin | 358 (92.7) | 88 (97.8) | 270 (91.2) | 0.03 |
| Fosfomycin | 209 (54.1) | 52 (57.8) | 157 (53.0) | 0.43 |
| Colistin | 37 (9.6) | 5 (5.6) | 32 (10.8) | 0.13 |
| Trimethoprim-sulfamethoxazole | 265 (68.7) | 63 (70.0) | 202 (68.2) | 0.75 |
| Sample (first isolate) | < 0.001 | |||
| Urine | 206 (53.4) | 74 (82.2) | 132 (44.6) | |
| Respiratory | 45 (11.7) | 7 (7.8) | 38 (12.8) | |
| Vascular catheter | 9 (2.3) | 3 (3.3) | 6 (2.0) | |
| Exudate | 43 (11.1) | 2 (2.2) | 41 (13.9) | |
| Blood | 50 (13.0) | 0 | 50 (16.9) | |
| Others | 33 (8.5) | 4 (4.4) | 29 (9.8) | |
aSeven isolates produced two carbapenemases