Table 3.
Features of patients with infections caused by carbapenemase-producing K. pneumoniae or E. coli, according to type of acquisition
| All infections (n = 296) | Community (n = 23) | Healthcare-associated (n = 130) | Nosocomial (n = 143) | P value | |
|---|---|---|---|---|---|
| Microorganism: K. pneumoniae | 280 (94.6) | 19 (81.6) | 127 (97.7) | 134 (93.7) | 0.010 |
| Carbapenemase typea | |||||
| OXA-48-like | 209 (70.6) | 18 (78.3) | 95 (73.1) | 96 (67.1) | 0.39 |
| KPC | 54 (18.2) | 2 (8.7) | 25 (19.2) | 27 (18.9) | 0.46 |
| Metallo-β-lactamases | 34 (11.5) | 2 (8.7) | 10 (7.7) | 22 (15.4) | 0.12 |
| Site of infection | < 0.001 | ||||
| Urinary | 150 (50.7) | 19 (82.6) | 89 (68.5) | 42 (29.4) | |
| Respiratory | 42 (14.2) | 1 (4.3) | 8 (6.2) | 33 (23.1) | |
| Soft tissues | 38 (12.8) | 2 (8.7) | 13 (10.0) | 23 (16.1) | |
| Intraabdominal | 33 (11.1) | 0 | 8 (6.1) | 25 (17.5) | |
| Catheter | 6 (2.0) | 0 | 2 (1.5) | 4 (2.8) | |
| Bacteremia, unknown source | 21 (7.1) | 1 (4.3) | 7 (5.4) | 13 (9.1) | |
| Others | 4 (1.4) | 0 | 2 (1.5) | 2 (1.4) | |
| Bloodstream infection, all sources | 68 (23.0) | 2 (8.7) | 23 (17.7) | 43 (30.1) | 0.012 |
| Surgical site infection | 23 (7.8 | 0 | 7 (5.4) | 16 (11.2) | 0.071 |
| Types of urinary tract infection | < 0.001 | ||||
| Afebrile, no device-associated | 54 (36.0) | 16 (84.2) | 33 (37.1) | 5 (11.9) | |
| Afebrile, device-associated | 21 (14.0) | 0 | 16 (18.0) | 5 (11.9) | |
| Febrile, no device-associated | 33 (22.0) | 3 (15.8) | 18 (20.2) | 12 (28.6) | |
| Febrile, device-associated | 42 (28.0) | 0 | 22 (24.7) | 20 (47.6) | |
| Severe sepsis or shock | 54 (18.2) | 2 (8.7) | 14 (10.8) | 38 (26.6) | 0.002 |
| Active empirical therapy | 55 (18.5) | 2 (8.7) | 17 (13.0) | 36 (25.1) | 0.02 |
| Mortality | 83 (28.0) | 3 (13.0) | 19 (14.6) | 61 (42.7) | < 0.001 |
aThree isolates produced two carbapenemases