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. 2024 Dec 6;9:37. doi: 10.1038/s41536-024-00381-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — PLGA-IMP treatment induces early accumulation of Tregs in NM-induced cutaneous wounds. a shows the increased frequency Tregs at the wound site following 2 doses of PLGA-IMP intervention. b, f show the significant increase in the Treg/Teff ratio after 2 and 3 doses of PLGA-IMP intervention, respectively. c, d, e show significant variation of T cell population and their functional markers in the wound, following 3 doses of PLGA-IMP intervention. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.