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. 2024 Dec 5;15:10631. doi: 10.1038/s41467-024-54673-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The German Mouse Clinic (GMC) phenotyping pipeline was conducted using 30 wildtype (WT, 15 males, 15 females) and 26 ∆Crossfirre-Firre-Dxz4 (TKO) mice (13 males, 13 females). The pipeline covered the screening tests from the following categories: immunology/allergy, behavior, biomarkers, cardiovascular, clinical chemistry, pathology, dysmorphology, eyes, metabolism, neurology, and nociception. b Visualization of key measured parameters to provide a general overview of the GMC screening pipeline results. The size of each triangle corresponds to the absolute effect size, represented by Cohen’s d. Triangles pointing up or down indicate upregulation or downregulation, respectively. Parameters with a p value < 0.05 are considered significant. N.S.: not significant (t-test). Additional parameter information, including p values, effect sizes (Cohen’s d, Hedges’ g), and parameter abbreviations are provided in Supplementary Data 1, sheets o–q. c Concise overview of the significant parameters as phenotypes for the groups TKO (n = 9), female-specific (n = 6), and male-specific (n = 13) by phenotyping category.