Table 4.
Multiple linear regression analysis of factors affecting the degree of cognitive impairment in first-episode schizophrenia patients
|
Dependent variable
|
Non standardized coefficient
|
Standard coefficient
|
t value
|
P value
|
95%CI of B
|
|||
|
B
|
Standard error
|
β
|
Lower limit
|
Upper limit
|
||||
| Information processing speed | Constant | 35.834 | 5.378 | 6.663 | 0.000 | 25.134 | 46.535 | |
| BDNF | 0.002 | 0.002 | 0.156 | 1.396 | 0.167 | -0.001 | 0.005 | |
| IL-6 | -0.173 | 0.088 | -0.218 | -2.039 | 0.046 | -0.349 | 0.003 | |
| Attention | Constant | 61.450 | 7.025 | 8.747 | 0.000 | 47.473 | 75.428 | |
| IL-6 | -0.492 | 0.114 | -0.426 | -4.329 | 0.000 | -0.718 | -0.266 | |
| IL-1β | -0.312 | 0.155 | -0.199 | -2.019 | 0.047 | -0.619 | -0.005 | |
| Working memory | Constant | 48.866 | 9.263 | 5.276 | 0.000 | 30.433 | 67.300 | |
| IL-1β | -0.230 | 0.150 | -0.155 | -1.532 | 0.129 | -0.529 | 0.069 | |
| BDNF | 0.004 | 0.002 | 0.192 | 1.793 | 0.077 | 0.000 | 0.008 | |
| IL-6 | -0.350 | 0.115 | -0.321 | -3.039 | 0.003 | -0.580 | -0.121 | |
| Comprehensive + execution ability | Constant | 52.628 | 8.983 | 5.858 | 0.000 | 34.751 | 70.505 | |
| IL-1β | -0.394 | 0.146 | -0.261 | -2.699 | 0.008 | -0.684 | -0.103 | |
| BDNF | 0.004 | 0.002 | 0.209 | 2.041 | 0.045 | 0.000 | 0.008 | |
| IL-6 | -0.362 | 0.112 | -0.327 | -3.242 | 0.002 | -0.585 | -0.140 | |
BDNF: Brain derived neurotrophic factor; IL: Interleukin.