Table 3.

The top 20 highest cited references

Journal	Finding	Year	Ranking	Citation	Ref.
Nature	Hypothalamic regulation of sleep and circadian rhythms	2005	1	1752	Saper et al[32]
Nature Medicine	A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains	2000	2	1566	Peyron et al[29]
Neuron	Reduced number of hypocretin neurons in human narcolepsy	2000	3	1530	Thannickal et al[34]
Lancet	Hypocretin (orexin) deficiency in human narcolepsy	2000	4	1315	Nishino et al[27]
Journal of Comparative Neurology	Differential expression of orexin receptors 1 and 2 in the rat brain	2001	5	1246	Marcus et al[25]
Sleep	Practice parameters for the indications for polysomnography and related procedures: An update for 2005	2005	6	1118	Kushida et al[53]
Neuron	Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity	2001	7	1085	Hara et al[19]
Trends in Neurosciences	The sleep switch: Hypothalamic control of sleep and wakefulness	2001	8	1081	Saper et al[30]
Nature	Neural substrates of awakening probed with optogenetic control of hypocretin neurons	2007	9	913	Adamantidis et al[18]
Neuron	Sleep state switching	2010	10	851	Saper et al[31]
Nature	A putative flip-flop switch for control of REM sleep	2006	11	810	Lu et al[24]
Archives of Neurology	The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias	2002	12	784	Mignot et al[26]
Sleep	Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. An American academy of sleep medicine report standards of practice committee of the American academy of sleep medicine	2005	13	724	Littner et al[23]
Neuron	Hypothalamic orexin neurons regulate arousal according to energy balance in mice	2003	14	694	Yamanaka et al[37]
Journal of Neuroscience	Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle	2005	15	642	Lee et al[22]
Movement Disorders	The REM sleep behavior disorder screening questionnaire: A new diagnostic instrument	2007	16	634	Stiasny-Kolster et al[33]
Annual Review of Neuroscience	To eat or to sleep? Orexin in the regulation of feeding and wakefulness	2001	17	564	Willie et al[35]
Brain	Rapid eye movement sleep behaviour disorder: Demographic, clinical and laboratory findings in 93 cases	2000	18	558	Olson et al[28]
Journal of Sleep Research	Sensitivity and specificity of the MSLT, the maintenance of wakefulness test and the Epworth sleepiness scale: Failure of the MSLT as a gold standard	2000	19	556	Johns[20]
Journal of Neuroscience	Dopaminergic role in stimulant-induced wakefulness	2001	20	548	Wisor et al[36]

MSLT: Multiple sleep latency test; REM: Rapid eye movement.