Table 2. Characteristics of included studies.

RCT, randomized controlled trial; U, university

Author and year of publication	Study design	Type of periodontitis	Country/setting	Masking	Informed consent	Follow-up
John et al. (2015) [17]	RCT split-mouth	Chronic periodontitis	India U	Single-blinded	Yes	3 months 0, 11 days, 11 weeks
Pattnaik et al. (2015) [18]	RCT split-mouth	Moderate to severe chronic periodontitis	India U	Double-blind	Yes	3 months 0, 1, 3 months
Paolantonio et al. (2008) [19]	RCT split-mouth multicenter study	Advanced periodontitis	Italy 4 U	Single-masked	Yes	6 months 0, 3, 6 months
Rodrigues et al. (2007) [20]	RCT parallel	Chronic periodontitis	Brazil U	Single-blinded	Yes	6 months 0, 6 weeks, 3, 6 months
Mızrak et al. (2006) [21]	RCT parallel	Chronic periodontitis	Turkey U	Single-blinded	Yes	6 months 0, 1, 3, 6 months
Grisi et al. (2002) [22]	RCT parallel	Chronic periodontitis	U Brazil	Single-blinded	Yes	9 months 3, 6, 9 months
Kondreddy et al. (2012) [23]	RCT split-mouth	Chronic periodontitis	India U	NA	Yes	6 months 0, 3, 6 months
Heasman et al. (2001) [24]	RCT split-mouth	Moderate to severe chronic periodontitis	UK U	Single-blinded	Yes	6 months 0, 1, 3, 6
Kasaj et al. (2007) [25]	RCT split-mouth	Moderate-to-severe chronic periodontitis	Germany U	Single-blinded	Yes	6 months 0, 1, 3, 6 months
Azmak et al. (2002) [26]	RCT split-mouth	Moderate to severe chronic periodontitis	Turkey U	Single-blinded	Yes	6 months 0, 1, 3, 6 months
Grover et al. (2011) [27]	RCT parallel	Mild to moderate chronic periodontitis	India U	Double-blind	Yes	3 months 0, 1, 2, 3