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. 2024 Nov 22;15:1448863. doi: 10.3389/fphar.2024.1448863

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Copyright © 2024 Liu, Wang, Xu, Guan, Zhang, Zhu, Liu, Zhu and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HD augments the expression of TJs and AJs in mice with DSS-induced acute colitis. Mice afflicted with enteritis received oral HD (3, 6, and 12 mg/kg) daily for 10 days (A) Western blot analysis of ZO-1, occludin, E-cadherin, and GAPDH in colon tissues. GAPDH as a control. (B) Densitometric evaluation of ZO-1, occludin, and E-cadherin. (C) Immunohistochemistry assessed the expression of ZO-1, occludin, and E-cadherin. Scale bar, 20 μm. Results are expressed as mean ± SEM (n = 3). ^# P < 0.05, ^## P < 0.01 vs. the normal group; *P < 0.05. **P < 0.01 vs. the DSS group, and ns indicates P > 0.05.