Fig. 4.

Kaplan-Meier survival curves for disease-free survival according to heterogeneity in TIL infiltration and its subset infiltration. (A) A significant difference in disease-free survival was noted between the group with uniformly high infiltration and the group with uniformly low infiltration as well as between the group with heterogeneous infiltration and the group exhibiting uniformly high infiltration (adjusted p = 0.009 for both). (B) Regarding CD4⁺ TIL subset infiltration, better prognosis was observed in groups with heterogeneous levels compared to those with consistently low levels (adjusted p = 0.003). (C) When disease-free survival was compared among the groups with different levels of heterogeneity of CD8⁺ TIL subset infiltration, no significant differences were observed between the groups. (D-F) Although not statistically significant, similar trends for poor survival were noted in both uniformly low and heterogeneous infiltration groups of CD56⁺, CD57⁺, and GNLY⁺ TIL subset. (G) When the disease-free survival was assessed among the groups divided based on the heterogeneity of GZMB⁺ TIL subset infiltration, no significant differences were observed among them