Table 1.
List of top 20 genes with a significant fold change in high-TIL group compared to low-TIL group
| Gene | Log2 fold change | p value | Adjusted p value |
|---|---|---|---|
| GNLY-mRNA | 1.78 | 1.60E-06 | 0.0063 |
| KLRC2-mRNA | 2.22 | 9.93E-06 | 0.0170 |
| CD83-mRNA | 0.80 | 1.29E-05 | 0.0170 |
| TGFB2-mRNA | -1.46 | 2.25E-05 | 0.0222 |
| CCL5-mRNA | 1.42 | 3.69E-05 | 0.0291 |
| CCR6-mRNA | 1.38 | 5.02E-05 | 0.0318 |
| SELL-mRNA | 1.36 | 5.64E-05 | 0.0318 |
| IL2RB-mRNA | 1.47 | 6.89E-05 | 0.0338 |
| ISG20-mRNA | 0.99 | 7.72E-05 | 0.0338 |
| GZMB-mRNA | 1.82 | 9.45E-05 | 0.0372 |
| TAP1-mRNA | 1.32 | 0.000183 | 0.0608 |
| PRF1-mRNA | 1.39 | 0.000185 | 0.0608 |
| MICB-mRNA | 1.03 | 0.000204 | 0.0619 |
| CCR7-mRNA | 1.61 | 0.000242 | 0.0668 |
| PSMB9-mRNA | 1.19 | 0.000254 | 0.0668 |
| SOCS1-mRNA | 1.15 | 0.000305 | 0.0704 |
| KLRK1-mRNA | 1.33 | 0.000308 | 0.0704 |
| NOD2-mRNA | 0.90 | 0.000343 | 0.0704 |
| CD247-mRNA | 1.23 | 0.000355 | 0.0704 |
| GZMM-mRNA | 1.27 | 0.000387 | 0.0704 |
Log2 fold changes were calculated using tumors with low levels of TIL infiltration as the baseline
p values were adjusted by Benzamini-Yekutieli procedure
TIL, tumor-infiltrating lymphocyte