Table 2.
Comparison of TIL subset and TIL ratio between low-TIL and high-TIL groups
| TIL subset or ratio | Low-TIL group (n = 48) | High-TIL group (n = 107) | p value |
|---|---|---|---|
| CD4+ TIL | 63.7 (31.9-121.2) | 288.3 (200.0-427.3) | < 0.001 |
| CD8+ TIL | 83.3 (43.7-142.3) | 279.7 (161.3-386.3) | < 0.001 |
| CD56+ TIL | 0.0 (0.0-0.7) | 3.3 (0.7–7.7) | < 0.001 |
| CD57+ TIL | 0.7 (0.0-3.2) | 10.7 (5.0-18.7) | < 0.001 |
| GNLY+ TIL | 1.3 (0.1–6.3) | 22.7 (11.3–46.0) | < 0.001 |
| GZMB+ TIL | 1.15 (0.0-5.2) | 15.0 (2.3–39.3) | < 0.001 |
| CD4+/CD8+ TIL | 0.64 (0.39–1.18) | 0.99 (0.73–1.53) | 0.002 |
| CD56+/CD8+ TIL | 0.00 (0.00-0.01) | 0.01 (0.00-0.02) | < 0.001 |
| CD57+/CD8+ TIL | 0.01 (0.00-0.03) | 0.04 (0.02–0.06) | < 0.001 |
| GNLY+/CD8+ TIL | 0.02 (0.00-0.06) | 0.09 (0.04–0.19) | < 0.001 |
| GZMB+/CD8+ TIL | 0.01 (0.00-0.06) | 0.06 (0.01–0.16) | 0.001 |
| CD56+/CD4+ TIL | 0.00 (0.00-0.01) | 0.01 (0.01–0.02) | < 0.001 |
| CD57+/CD4+ TIL | 0.01 (0.00-0.04) | 0.04 (0.02–0.07) | < 0.001 |
| GNLY+/CD4+ TIL | 0.03 (0.01–0.07) | 0.08 (0.04–0.18) | < 0.001 |
| GZMB+/CD4+ TIL | 0.02 (0.00-0.08) | 0.04 (0.01–0.16) | 0.029 |
Data are presented as median (inter-quartile range), and p values were calculated by Mann-Whitney U test
TIL, tumor-infiltrating lymphocyte; GNLY, granulysin; GZMB, granzyme B