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Common PPI and their interaction with CYP isoenzymes.
| PPI | CYP enzyme (strength of inhibition) | Common dosing |
|---|---|---|
| Pantoprazole | CYP2C19 (weak inhibitor) | 40 mg once daily |
| Omeprazole | CYP2C19 (moderate inhibitor) | 20 mg once daily |
| Esomeprazole | CYP2C19 (moderate inhibitor) | 20 mg–40 mg once daily |
| Rabeprazole | CYP2C19 (weak inhibitor) | 20 mg once daily |
| Lansoprazole | CYP2C19 (moderate inhibitor), CYP3A4 (weak inhibitor) | 15 mg–30 mg once daily |
