Table 3.

Common antiplatelet drugs and metabolic pathway.

Drug	Mechanism of action	Pro-drug	Metabolized by CYP (isoenzyme)	Common prescribed dose
Clopidogrel	P2Y12 receptor antagonist	Yes	Yes (CYP2C19, CYP3A4)	75 mg once daily (loading dose of 300–600 mg)
Ticagrelor	P2Y12 receptor antagonist	No	Yes (CYP3A4, CYP3A5)	90 mg twice daily (loading dose of 180 mg)
Prasugrel	P2Y12 receptor antagonist	Yes	Yes (CYP3A4, CYP2B6)	10 mg once daily (loading dose of 60 mg)
Aspirin	COX-1 inhibitor	No	No	75–162 mg once daily (loading dose of 324 mg)

COX-1: Cyclooxygenase-1; CYP: Cytochrome P450.