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. Author manuscript; available in PMC: 2024 Dec 6.
Published in final edited form as: JAMA Surg. 2024 Aug 1;159(8):949–956. doi: 10.1001/jamasurg.2024.0429

Table 1.

Proposed 5-Part Framework for Stewardship of Surgical Antibiotic Prophylaxis

Framework for Stewardship of Surgical Antibiotic Prophylaxis
  1. Avoid antibiotics in contexts where studies indicate they are not beneficial

  2. Consider antimicrobial strategies with lower-risk profiles

  3. Maximize the effect of antibiotic prophylaxis through more targeted use

  4. Leverage nonantibiotic surgical site infection prevention measures

  5. Consider new models of surgical site infection pathogenesis