Figure 1.

mRNA expression analysis of genes related to miRNA biogenesis in adrenocortical carcinoma (ACC) and normal adrenal cortex (NAC) tissue samples. The expression levels of miRNA biogenesis genes (AGO2, DROSHA, DGCR8, XPO5, RAN, TARBP2, and DICER1) were compared in ACC and normal adrenal cortex tissue samples using RNA-Seq data from the TCGA and GTEX datasets. Among these genes, AGO2 showed significantly higher expression in ACC samples than in normal samples (P < 0.001), whereas minimal or no expression of AGO2 was detected in normal samples. A full-color version of this figure is available at https://doi.org/10.1530/ERC-24-0061.