Figure 2.

Association between miRNA biogenesis gene expression and survival rates in adrenocortical carcinoma (ACC) patients. Gene survival analysis of TCGA RNA-seq data was performed to explore overall survival rates in 79 ACC patients with adrenocortical carcinoma according to high (green) or low (brown) gene expression levels. The analysis revealed a poor prognosis associated with high expression levels of AGO2, DGCR8, XPO5, and RAN, with log-rank P <0.001. TARBP2 showed a weaker prognostic association (log-rank P = 0.014). DROSHA and DICER did not exhibit significant prognostic correlations, with log-rank P = 0.85 and P = 0.57, respectively. Among the genes involved in the miRNA biogenesis pathway, AGO2 emerged as the strongest prognostic indicator in ACC, exhibiting a hazard ratio (HR) of 7.07 and a log-rank test P-value of 2.8e-06.