Figure 5.

Receiver operating characteristic (ROC) curve for AGO2 protein expression in adrenocortical carcinoma (ACC) patients. The ROC curve illustrates the diagnostic ability of AGO2 protein expression to differentiate between ACC and non-malignant samples. The area under the curve (AUC) was 0.9481 (95% CI: 0.8641 to 1.000), indicating high diagnostic accuracy. A cut-off value of >3.9 for AGO2 protein expression yielded a sensitivity of 88.89% (95% CI: 56.50% to 99.43%) and a specificity of 80.00% (95% CI: 54.81% to 92.95%). The diagonal dashed line represents the line of no discrimination (AUC = 0.5).