Figure 6.

Association of AGO2 expression with overall survival (OS) and excess adrenal hormone history in ACC. AGO2 gene expression (log2-transformed) is shown across different hormone production statuses in ACC patients from the TCGA-ACC cohort: No excess hormone production, Cortisol, Androgen, and Androgen|Cortisol. Across all groups, deceased patients (red) have higher AGO2 expression compared to those alive, indicating that elevated AGO2 is associated with poor survival outcomes. Notably, even patients with no excess hormone production show a positive correlation between AGO2 expression and survival, highlighting AGO2 as a potentially better prognostic marker than hormone production status alone.