Table 2.

Known siNET cell lines, their origin, immunohistochemical profile, growth profile, and original publication.

Cell line (original publication)	Origin	Immunohistochemical profile	Growth profile	References
P-STS	G3 tumor of the terminal ileum	Pan-CK, serotonin, CD56, Syp, HISL19, NSE	Doubling time: 4 days–1 week, grows in mildly adherent culture with some non-adherent aggregates	Pfragner et al. (2009), Hofving et al. (2018)
GOT-1	G1 carcinoid tumor liver metastasis	CgA, 5-HT, VMAT1, serotonin, NCAM	Doubling time: 18 days	Kölby et al. (2001), Hofving et al. (2018)
CNDT2.5	G1 liver metastasis from an ileal carcinoid	Syp, NSE, produced serotonin, SSTR1-5	Limited published data	Van Buren et al. (2007), Barazeghi et al. (2021)
HC45	G1 liver metastasis from an ileal carcinoid	CgA, CgB, SSTR2, SSTR5, Syp, VMAT 1, vitamin D3 receptor	Limited published data	Stilling et al. (2007)
SS-C	Jejunal somatostatinoma	SSTR2, NSE, CgA, Syp	Doubling time: 3–6 days	Galli et al. (2006)
STC-1 (mouse)	Tumor from the duodenum of a RIP1Tag2/RIP2PyST1 mouse	Secretin, gastrin, somatostanin, CgA	Doubling time: 54 h	Rindi et al. (1990)