Table 3.

Current murine models of small intestinal neuroendocrine tumors.

Model	Type	Location	Notes	References
Transgenic, carrying insulin-promoted oncogenes	GEMM	Small intestine	Secreted secretin, proglucagon-related peptides, glucose-dependent insulinotropic polypeptide, among others. Large T-antigen immunoreactivity	Rindi et al. (1990)
GOT1 CDX/BALB/cABom-nu	Cell xenograft	Subcutaneous, back of the neck	IHC positive for major NET markers (CgA, Syp, NCAM)	Kölby et al. (2001)
Low-grade LM PDX/NOG	Tumor xenograft	Subcutaneous, hepatic orthotopic	Hepatic orthotopic was not successful, some cells from SQ were positive for NET markers	Hofving et al. (2021b)
CNDT2.5 PDX/NMRI-nude female	Cell xenograft	Subcutaneous, hind flank	Cells embedded in Matrigel, cells positive for Syp	Barazeghi et al. (2021)
RT2 transgenic mice, B6AF1 background	GEMM	Ileum	Tumors noted to have high expression of IGF2, which is a potential driver of tumorigenesis	Contractor et al. (2020)