Table 3. Exercise intervention significantly decreases fall rate in E4 carriers.

Fall rate per 1,000 participant-days1
Genotype	Month	N	Mean fall rate	Genotype	Month	N	Mean fall rate
E2−	B	109	3.47	E4−	B	97	2.52
	1	109	4.89		1	97	5.50
	3	106	1.89		3	94	2.13
	6	105	2.54		6	93	2.87
	9	105	1.59		9	93	2.15
	12	105	2.54		12	93	3.94
E2+	B	17	1.63	E4+	B	29	5.56
	1	17	7.84		1	29	4.60
	3	16	4.17		3	28	2.38
	6	16	6.25		6	28	3.57
	9	16	2.08		9	28	0*
	12	16	6.25		12	28	0***

¹Fall rate was calculated as (# participant-falls/# participant-days) × 1000. The fall rate of E4 carriers per 1000 participant-days decreased from 5.56 falls per 1000 participant days to 0 from baseline to month 12 (p = 0.043). There was a trend toward higher fall rate among E4 carriers versus E4 non-carriers at baseline (2.52 per 1000 participant-days versus 5.56, p = 0.059). However, after exercise intervention, E4 carriers demonstrated a significantly lower fall rate when compared with E4 non-carriers at both the 9 (2.15 versus 0, ^* p = 0.013) and 12 month (3.94 versus 0, ^*** p = 0.002) time periods. Abbreviation: B: baseline.