Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1980 Oct 15;192(1):377–380. doi: 10.1042/bj1920377

Effect of glucose on carbohydrate synthesis from alanine or lactate in hepatocytes from starved rats.

K Solanki, F Nyfeler, U K Moser, P Walter
PMCID: PMC1162346  PMID: 7305909

Abstract

In hepatocytes from starved rats, 10mM-glucose suppressed in incorporation of 2mM labelled alanine into glucose+glycogen by more than 40%, whereas no inhibition was observed with labelled lactate as substrate. Addition of glycerol instead of glucose did not show this inhibition. The inhibitory effect could also be demonstrated in label-free experiments.

Full text

PDF
377

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chen R. F. Removal of fatty acids from serum albumin by charcoal treatment. J Biol Chem. 1967 Jan 25;242(2):173–181. [PubMed] [Google Scholar]
  2. Claus T. H., Pilkis S. J., Park C. R. Stimulation by glucagon of the incorporation of U-14C-labeled substrates into glucose by isolated hepatocytes from fed rats. Biochim Biophys Acta. 1975 Sep 8;404(1):110–123. doi: 10.1016/0304-4165(75)90152-x. [DOI] [PubMed] [Google Scholar]
  3. Exton J. H., Park C. R. Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats. J Biol Chem. 1967 Jun 10;242(11):2622–2636. [PubMed] [Google Scholar]
  4. Feliú J. E., Hue L., Hers H. G. Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2762–2766. doi: 10.1073/pnas.73.8.2762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nyfeler F., Walter P. Effect of lithium on glycogen synthesis in hepatocytes from rat liver. FEBS Lett. 1979 Dec 1;108(1):197–199. doi: 10.1016/0014-5793(79)81209-0. [DOI] [PubMed] [Google Scholar]
  6. Ruderman N. B., Herrera M. G. Glucose regulation of hepatic gluconeogenesis. Am J Physiol. 1968 Jun;214(6):1346–1351. doi: 10.1152/ajplegacy.1968.214.6.1346. [DOI] [PubMed] [Google Scholar]
  7. WALAAS O., WALAAS E. Effect of epinephrine on rat diaphragm. J Biol Chem. 1950 Dec;187(2):769–776. [PubMed] [Google Scholar]
  8. Weibel E. R., Stäubli W., Gnägi H. R., Hess F. A. Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver. J Cell Biol. 1969 Jul;42(1):68–91. doi: 10.1083/jcb.42.1.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wheatley D. N. Binucleation in mammalian liver. Studies on the control of cytokinesis in vivo. Exp Cell Res. 1972 Oct;74(2):455–465. doi: 10.1016/0014-4827(72)90401-6. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES