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. Author manuscript; available in PMC: 2025 Feb 1.
Published in final edited form as: Nat Chem Biol. 2023 Nov 9;20(2):243–250. doi: 10.1038/s41589-023-01476-2

Fig. 3 |. TnmJ catalyzes the SAM-independent cofactorless cryptic oxidation of TNM I (8).

Fig. 3 |

a, HPLC analysis, with detection at 539 nm and 460 nm, of the in vitro TnmJ-catalyzed conversion of TNM I (8) to TNM J (13). std, standard. b, The homodimeric apo-structure of TnmJ has a characteristic α,β-Rossmann methyltransferase fold, with one monomer depicted in red. c, The active site of TnmJ with 8 docked based on results from a 100-ns molecular dynamics simulation depicts key residues implicated in binding and catalysis.