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. 2024 Dec 6;9(23):e184396. doi: 10.1172/jci.insight.184396

Figure 5. RNA-Seq analysis reveals profound and unique effects of KHK KD versus inhibition on hepatic transcriptome.

Figure 5

(A) Principal component analysis of RNA-Seq data from the livers of our experimental mice. (B) A heatmap representation of the top 40 genes plus KHK. (C) Heatmap of the DNL pathway and (D) the FAO pathway. Volcano plot comparison of (E) HFD and LFD, (F) HFD and HFD + siRNA, (G) HFD and HFD + Inhibitor, and (H) HFD + siRNA and HFD + Inhibitor. Reactome pathway analysis showing the most significantly altered pathways between (I) HFD + siRNA versus HFD group and (J) HFD + Inhibitor versus HFD group.