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. 2024 Nov 4;25(12):5667–5686. doi: 10.1038/s44319-024-00305-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) MPP7-L27 contributes to MPP7-TAZ interaction by co-IP assay in 293T cells. Expression constructs and tagged epitopes for detection are indicated; (−), empty vector; quantification to the right. (B) Relative TEAD-reporter activities when co-transfected with various Mpp7 constructs (x-axis); (−), empty vector. n = 3 individual experiments. (C) Model summarizes the co-IP results in (A, Appendix Fig. S5A,B). (D) Diagram for the fusion construct of V5-tagged Mpp7-L27 and Taz (i.e., L27-Taz) used in (E, F). (G) Relative TEAD-reporter activities when co-transfected with constructs indicated in the x-axis; (−), empty expression construct. (H) Quantification of cell fates of Con and Mpp7 cKO MuSCs in SM assay; expression constructs in the x-axis; Con (−) and Mpp7 cKO (−) from Fig. 2C. Data information: (A, B, E) n = 3 biological replicates; (F) ≥ 150 cells in each group. Error bars represent means ± SD in (A, B, E). One-way ANOVA with Tukey’s post hoc test was performed in (A, B, E), and Chi-Squire test in (F). Source data are available online for this figure.