Table 2.
Individual AA quantitative range, R2, qualitive control signal, instrument and method repeatabilities, and recovery
| AA | Standard curve linear range (μmol/L) | Standard curve signal range (V/min) | R2 | QC1 signal range (V/min) | QC (μmol/L) | Instrument repeatability (%) | Method repeatability (%) | Total repeatability (%) | Recovery (%) |
|---|---|---|---|---|---|---|---|---|---|
| Asp | 0.27–52.6 | 12,592–2,150,700 | 0.9999 | 76,042–114,554 | 4.8 | 1.11 | 2.56 | 2.72 | 86.2 |
| Glu2 | 3.81–292.89 | 70,562–8,592,941 | 0.9999 | 707,437–1,037,916 | 58.8 | 0.56 | 2.52 | 2.56 | 97.1 |
| Asn | 1.64–315.52 | 4,473–2,906,556 | 0.9999 | 87,995–147,824 | 53.6 | 1.53 | 1.94 | 2.31 | 94.5 |
| Gln | 4.45–855.74 | 16,060–7,262,293 | 0.9999 | 602,215–934,404 | 273.7 | 0.50 | 2.39 | 2.42 | 95.4 |
| His | 0.93–179.12 | 28,189–3,697,592 | 0.9998 | 446,655–568,939 | 41.1 | 1.13 | 1.99 | 2.19 | 97.6 |
| Ser | 2.8–538.34 | 25,254–5,854,739 | 0.9999 | 485,735–751,310 | 110.8 | 0.66 | 1.89 | 1.97 | 97.6 |
| Gly2 | 8.24–328.35 | 13,932–457,164 | 0.9995 | 156,011–213,717 | 296.6 | 1.18 | 2.12 | 2.33 | 93.7 |
| Thr | 2.9–558.25 | 36,551–10,799,604 | 0.9998 | 203,194–373,786 | 85.9 | 0.77 | 2.43 | 2.51 | 99.7 |
| Ala | 6.14–1,180.91 | 35,808–4,506,686 | 0.9999 | 53,657–71,804 | 281.9 | 1.00 | 1.89 | 2.06 | 92.6 |
| Arg | 3.08–592.55 | 8,784–1,190,030 | 0.9999 | 56,582–81,641 | 62.2 | 2.29 | 3.34 | 3.83 | 90.4 |
| Pro | 2.65–508.63 | 140,316–14,267,622 | 0.9996 | 4,258,770–4,647,082 | 104.6 | 0.63 | 1.67 | 1.75 | 96.6 |
| Tyr | 2.1–403.09 | 7,743–1,578,059 | 0.9999 | 109,304–128,470 | 97.9 | 0.53 | 1.14 | 1.22 | 97.0 |
| Val | 6.57–1,262.37 | 57,661–5,073,884 | 0.9998 | 1,169,823–1,359,375 | 224.7 | 0.33 | 1.79 | 1.81 | 98.6 |
| Met | 0.48–93.18 | 7,212–670,589 | 0.9998 | 43,071–53,907 | 21.3 | 0.40 | 1.51 | 1.54 | 102.1 |
| Ile | 3.27–628.04 | 34,063–2,536,612 | 0.9998 | 819,336–908,762 | 116.2 | 0.49 | 1.68 | 1.72 | 98.6 |
| Leu | 4.06–779.37 | 25,759–1,893,897 | 0.9997 | 867,042–959,339 | 199.5 | 0.55 | 1.25 | 1.33 | 96.1 |
| Trp | 1.24–238.14 | 26,114–341,176 | 0.9993 | 98,759–137,102 | 43.4 | 1.68 | 1.65 | 2.15 | 91.2 |
| Phe | 1.34–258.36 | 17,766–1,588,804 | 0.9999 | 489,834–600,854 | 49.2 | 0.38 | 1.64 | 1.67 | 95.7 |
| Lys | 2.68–515.99 | 21,588–592,032 | 0.9994 | 46,301–102,596 | 84 | 1.62 | 2.94 | 3.22 | 96.7 |
QC = quality control samples pooled from plasma samples from lactating dairy cows consuming 15% to 16.5% CP diets. Signal range and average concentration of 5 independent aliquots.
Curve points were removed from Glu (highest and lowest: 366.8 and 1.91 μM, respectively) and Gly (4 highest: 1,652.67 to 664.06 μM) to preserve linearity.