Table 1.
Linear regression variables for abomasal infusion of dl-Met and fed Smartamine M (SM), and relative bioavailability (RBV) and 95% CI for SM as determined in the individual and combined sampling periods
| Item1 | Infused dl-Met | Fed SM |
|---|---|---|
| 2–8 h after 0500 h feeding | ||
| Slope | 1.372 | 1.153 |
| SEM of slope | 0.05 | 0.04 |
| R2 | 0.98 | 0.99 |
| RBV, % | — | 83.84 |
| CI | — | 77.3–90.2 |
| 2–8 h after 1300 h feeding | ||
| Slope | 1.382 | 1.163 |
| SEM of slope | 0.05 | 0.04 |
| R2 | 0.98 | 0.98 |
| RBV, % | — | 83.64 |
| CI | — | 77.1–90.1 |
| 2–8 h after 2100 h feeding | ||
| Slope | 1.372 | 1.203 |
| SEM of slope | 0.06 | 0.04 |
| R2 | 0.98 | 0.99 |
| RBV, % | — | 87.44 |
| CI | — | 79.0–95.8 |
| Within a 24-h period | ||
| Slope | 1.372 | 1.163 |
| SEM of slope | 0.05 | 0.03 |
| R2 | 0.98 | 0.99 |
| RBV, % | — | 84.84 |
| CI | — | 80.6–89.0 |
1
Blood samples were collected every 2 h for 3 d and analyzed Met concentrations pooled across day before statistical analysis.
2
Slopes for the infused dl-Met treatments were not different from each other (P = 0.97).
3
Slopes for the SM treatments were not different from each other (P = 0.75).
4
RBV estimates, calculated as RBV = (slope of SM fed/slope of dl-Met infused) × 100, were not different from each other (P = 0.82).