Table 2.

The Mendelian Randomization analysis between ankylosing spondylitis on diabetes and diabetes-related clinical index based on MR-Egger, Weighted median, and Weighted mode methods.

Exposure	Outcome	Sources	N_SNP	MR-Egger						Weighted median						Weighted mode
				beta	se	Pval	OR	lower95%CI	upper95%CI	beta	se	Pval	OR	lower95%CI	upper95%CI	beta	se	Pval	OR	lower95%CI	upper95%CI
Ankylosing spondylitis	T1D	ebi-a-GCST005536	17	0.760	0.486	0.139	2.137	0.825	5.536	0.589	0.199	0.003	1.802	1.220	2.663	0.664	0.278	0.030	1.943	1.126	3.350
		ebi-a-GCST010681	20	1.015	0.541	0.077	2.759	0.956	7.966	0.600	0.251	0.017	1.822	1.115	2.977	1.124	0.396	0.011	3.077	1.415	6.689
		ebi-a-GCST90000529	20	1.054	0.478	0.041	2.869	1.124	7.323	0.540	0.214	0.012	1.717	1.129	2.610	0.632	0.226	0.012	1.882	1.207	2.933
		finn-b-T1D_WIDE	20	1.162	0.542	0.046	3.197	1.105	9.249	0.662	0.217	0.002	1.939	1.266	2.970	0.768	0.266	0.009	2.156	1.280	3.631
	T2D	ebi-a-GCST006867	16	0.023	0.064	0.720	1.023	0.904	1.159	0.041	0.045	0.355	1.042	0.955	1.137	0.045	0.046	0.348	1.046	0.955	1.146
		ebi-a-GCST010118	21	0.139	0.062	0.039	1.149	1.017	1.299	0.128	0.041	0.002	1.137	1.049	1.233	0.111	0.039	0.010	1.117	1.034	1.206
		ebi-a-GCST007515	4	-0.032	0.102	0.784	0.969	0.793	1.183	0.039	0.041	0.339	1.040	0.960	1.126	0.038	0.044	0.450	1.039	0.953	1.133
		ebi-a-GCST005413	24	0.202	0.275	0.470	1.224	0.714	2.096	0.167	0.156	0.283	1.182	0.871	1.605	-0.117	0.239	0.629	0.889	0.557	1.421
		ieu-a-23	20	-0.171	0.130	0.204	0.842	0.653	1.087	-0.139	0.085	0.099	0.870	0.737	1.027	-0.139	0.078	0.090	0.870	0.747	1.014
		ieu-a-24	7	-0.238	0.135	0.138	0.788	0.605	1.027	-0.033	0.076	0.662	0.967	0.833	1.123	-0.030	0.072	0.690	0.970	0.842	1.118
		FinnGen_R9_T2D	22	0.020	0.072	0.780	1.021	0.886	1.176	0.020	0.042	0.638	1.020	0.940	1.107	0.016	0.045	0.722	1.016	0.931	1.109
	Fasting insulin	ebi-a-GCST90002238	25	-0.027	0.023	0.250	0.973	0.930	1.018	-0.032	0.013	0.011	0.968	0.944	0.993	-0.029	0.013	0.039	0.972	0.947	0.997
		ieu-b-115	19	-0.012	0.030	0.690	0.988	0.931	1.048	-0.029	0.020	0.143	0.972	0.935	1.010	-0.022	0.020	0.279	0.978	0.941	1.017
		ieu-b-116	5	-0.033	0.019	0.175	0.967	0.932	1.004	-0.021	0.013	0.106	0.979	0.955	1.004	-0.022	0.013	0.171	0.978	0.954	1.004
		ebi-a-GCST000571	19	-0.017	0.037	0.648	0.983	0.915	1.057	-0.040	0.024	0.100	0.961	0.917	1.008	-0.027	0.025	0.296	0.974	0.927	1.022
		ebi-a-GCST007857	4	0.004	0.040	0.934	1.004	0.928	1.086	0.015	0.023	0.533	1.015	0.969	1.062	0.014	0.023	0.578	1.014	0.970	1.061
		ebi-a-GCST008033	25	-0.046	0.079	0.568	0.955	0.818	1.116	-0.043	0.062	0.486	0.958	0.849	1.081	-0.044	0.059	0.461	0.957	0.852	1.074
	Glycated hemoglobin	ebi-a-GCST90002244	22	-0.008	0.013	0.537	0.992	0.966	1.018	-0.006	0.008	0.451	0.994	0.978	1.010	-0.005	0.008	0.508	0.995	0.979	1.010
		ukb-d-30750_irnt	17	0.105	0.053	0.067	1.111	1.001	1.232	0.061	0.024	0.011	1.063	1.014	1.114	0.059	0.027	0.045	1.061	1.006	1.120
	Blood glucose	ebi-a-GCST005186	19	0.019	0.024	0.450	1.019	0.972	1.068	0.024	0.019	0.201	1.024	0.987	1.062	0.021	0.018	0.248	1.022	0.986	1.058
		ebi-a-GCST000568	19	-0.003	0.029	0.928	0.997	0.943	1.055	0.015	0.022	0.483	1.015	0.973	1.060	0.013	0.020	0.532	1.013	0.973	1.054
		ebi-a-GCST007858	4	0.050	0.038	0.317	1.051	0.976	1.132	0.050	0.022	0.025	1.051	1.006	1.097	0.052	0.024	0.116	1.054	1.005	1.104
	Fasting glucose	ebi-a-GCST90002232	24	0.014	0.018	0.428	1.014	0.980	1.050	0.008	0.012	0.476	1.008	0.985	1.032	0.012	0.012	0.299	1.012	0.990	1.036
		ieu-b-114	4	0.012	0.020	0.612	1.012	0.973	1.053	0.014	0.013	0.277	1.014	0.989	1.041	0.014	0.014	0.378	1.015	0.987	1.043
		ieu-b-113	19	0.019	0.024	0.450	1.019	0.972	1.068	0.024	0.019	0.204	1.024	0.987	1.062	0.021	0.017	0.219	1.022	0.989	1.056

T1D, Type 1 diabetes; T2D, Type 2 diabetes.