Table 3.
Exposure | Outcome | Sources | N_SNP | MR-PRESSO | Egger_intercept | Pval | Q_statistics | Pval | Heterogeneity_I2% | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
beta | se | Pval | GlobalTest_Pval | |||||||||
Ankylosing spondylitis | T1D | ebi-a-GCST005536 | 17 | 0.415 | 0.183 | 0.037 | 0.009 | -0.014 | 0.455 | 32.865 | 0.008 | 51 |
ebi-a-GCST010681 | 20 | 0.573 | 0.231 | 0.023 | 0.001 | -0.020 | 0.377 | 46.800 | 0.000 | 59 | ||
ebi-a-GCST90000529 | 20 | 0.474 | 0.210 | 0.036 | 0.001 | -0.026 | 0.196 | 45.325 | 0.001 | 58 | ||
finn-b-T1D_WIDE | 20 | 0.401 | 0.190 | 0.049 | 0.026 | -0.028 | 0.152 | 32.953 | 0.024 | 42 | ||
T2D | ebi-a-GCST006867 | 16 | 0.029 | 0.037 | 0.451 | 0.492 | 0.000 | 0.917 | 15.356 | 0.426 | 2 | |
ebi-a-GCST010118 | 21 | 0.087 | 0.037 | 0.030 | 0.159 | -0.003 | 0.313 | 27.718 | 0.116 | 28 | ||
ebi-a-GCST007515 | 4 | 0.038 | 0.059 | 0.565 | 0.443 | 0.008 | 0.480 | 6.613 | 0.085 | 55 | ||
ebi-a-GCST005413 | 24 | 0.170 | 0.114 | 0.149 | 0.091 | -0.001 | 0.899 | 32.034 | 0.099 | 28 | ||
ieu-a-23 | 20 | -0.083 | 0.076 | 0.287 | 0.170 | 0.006 | 0.412 | 26.344 | 0.121 | 28 | ||
ieu-a-24 | 7 | 0.042 | 0.136 | 0.766 | 0.242 | 0.029 | 0.036 | 20.529 | 0.002 | 71 | ||
FinnGen_R9_T2D | 22 | 0.034 | 0.041 | 0.418 | 0.017 | 0.001 | 0.814 | 39.234 | 0.009 | 46 | ||
Fasting insulin | ebi-a-GCST90002238 | 25 | -0.023 | 0.013 | 0.092 | 0.004 | 0.000 | 0.829 | 48.580 | 0.002 | 51 | |
ieu-b-115 | 19 | -0.030 | 0.018 | 0.115 | 0.102 | -0.001 | 0.473 | 26.548 | 0.088 | 32 | ||
ieu-b-116 | 5 | -0.016 | 0.011 | 0.213 | 0.485 | 0.002 | 0.295 | 2.795 | 0.593 | 0 | ||
ebi-a-GCST000571 | 19 | -0.027 | 0.022 | 0.222 | 0.143 | -0.001 | 0.731 | 25.781 | 0.105 | 30 | ||
ebi-a-GCST007857 | 4 | 0.023 | 0.016 | 0.230 | 0.542 | 0.002 | 0.610 | 1.412 | 0.703 | 0 | ||
ebi-a-GCST008033 | 25 | -0.076 | 0.046 | 0.108 | 0.419 | -0.002 | 0.640 | 25.217 | 0.394 | 5 | ||
Glycated hemoglobin | ebi-a-GCST90002244 | 22 | 0.002 | 0.008 | 0.839 | 0.060 | 0.001 | 0.362 | 34.267 | 0.034 | 39 | |
ukb-d-30750_irnt | 17 | 0.057 | 0.021 | 0.017 | 0.046 | -0.002 | 0.338 | 27.173 | 0.040 | 41 | ||
Blood glucose | ebi-a-GCST005186 | 19 | 0.025 | 0.014 | 0.094 | 0.624 | 0.000 | 0.745 | 16.837 | 0.534 | 0 | |
ebi-a-GCST000568 | 19 | 0.018 | 0.017 | 0.304 | 0.621 | 0.001 | 0.383 | 16.933 | 0.528 | 0 | ||
ebi-a-GCST007858 | 4 | 0.051 | 0.015 | 0.047 | 0.719 | 0.000 | 0.986 | 1.548 | 0.671 | 0 | ||
Fasting glucose | ebi-a-GCST90002232 | 24 | 0.014 | 0.010 | 0.188 | 0.112 | 0.000 | 0.963 | 33.185 | 0.078 | 31 | |
ieu-b-114 | 4 | 0.015 | 0.008 | 0.159 | 0.881 | 0.000 | 0.885 | 1.141 | 0.767 | 0 | ||
ieu-b-113 | 19 | 0.025 | 0.014 | 0.094 | 0.643 | 0.000 | 0.745 | 16.837 | 0.534 | 0 |
T1D, Type 1 diabetes; T2D, Type 2 diabetes.