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. 2024 Nov 22;15:1369466. doi: 10.3389/fendo.2024.1369466

Table 3.

The sensitivity analysis between ankylosing spondylitis on diabetes and diabetes-related clinical index by MR-PRESSO, Egger intercept, Q-test, and heterogeneity I2 methods.

Exposure Outcome Sources N_SNP MR-PRESSO Egger_intercept Pval Q_statistics Pval Heterogeneity_I2%
beta se Pval GlobalTest_Pval
Ankylosing spondylitis T1D ebi-a-GCST005536 17 0.415 0.183 0.037 0.009 -0.014 0.455 32.865 0.008 51
ebi-a-GCST010681 20 0.573 0.231 0.023 0.001 -0.020 0.377 46.800 0.000 59
ebi-a-GCST90000529 20 0.474 0.210 0.036 0.001 -0.026 0.196 45.325 0.001 58
finn-b-T1D_WIDE 20 0.401 0.190 0.049 0.026 -0.028 0.152 32.953 0.024 42
T2D ebi-a-GCST006867 16 0.029 0.037 0.451 0.492 0.000 0.917 15.356 0.426 2
ebi-a-GCST010118 21 0.087 0.037 0.030 0.159 -0.003 0.313 27.718 0.116 28
ebi-a-GCST007515 4 0.038 0.059 0.565 0.443 0.008 0.480 6.613 0.085 55
ebi-a-GCST005413 24 0.170 0.114 0.149 0.091 -0.001 0.899 32.034 0.099 28
ieu-a-23 20 -0.083 0.076 0.287 0.170 0.006 0.412 26.344 0.121 28
ieu-a-24 7 0.042 0.136 0.766 0.242 0.029 0.036 20.529 0.002 71
FinnGen_R9_T2D 22 0.034 0.041 0.418 0.017 0.001 0.814 39.234 0.009 46
Fasting insulin ebi-a-GCST90002238 25 -0.023 0.013 0.092 0.004 0.000 0.829 48.580 0.002 51
ieu-b-115 19 -0.030 0.018 0.115 0.102 -0.001 0.473 26.548 0.088 32
ieu-b-116 5 -0.016 0.011 0.213 0.485 0.002 0.295 2.795 0.593 0
ebi-a-GCST000571 19 -0.027 0.022 0.222 0.143 -0.001 0.731 25.781 0.105 30
ebi-a-GCST007857 4 0.023 0.016 0.230 0.542 0.002 0.610 1.412 0.703 0
ebi-a-GCST008033 25 -0.076 0.046 0.108 0.419 -0.002 0.640 25.217 0.394 5
Glycated hemoglobin ebi-a-GCST90002244 22 0.002 0.008 0.839 0.060 0.001 0.362 34.267 0.034 39
ukb-d-30750_irnt 17 0.057 0.021 0.017 0.046 -0.002 0.338 27.173 0.040 41
Blood glucose ebi-a-GCST005186 19 0.025 0.014 0.094 0.624 0.000 0.745 16.837 0.534 0
ebi-a-GCST000568 19 0.018 0.017 0.304 0.621 0.001 0.383 16.933 0.528 0
ebi-a-GCST007858 4 0.051 0.015 0.047 0.719 0.000 0.986 1.548 0.671 0
Fasting glucose ebi-a-GCST90002232 24 0.014 0.010 0.188 0.112 0.000 0.963 33.185 0.078 31
ieu-b-114 4 0.015 0.008 0.159 0.881 0.000 0.885 1.141 0.767 0
ieu-b-113 19 0.025 0.014 0.094 0.643 0.000 0.745 16.837 0.534 0

T1D, Type 1 diabetes; T2D, Type 2 diabetes.