Figure 9.

Results of the FAVOR III China multicenter randomized trial comparing angiographic quantitative flow ratio-guided vs. angiography-guided coronary interventions (A) and the clinical implications of quantitative flow ratio after a percutaneous coronary intervention in the SYNTAX II trial (B) and HAWKEYE study (C). (A) Kaplan–Meier curves for the primary endpoints in the intention-to-treat population showed that among patients undergoing a PCI with a QFR-guided strategy for lesion selection had improved 1-year clinical outcomes compared with standard angiography guidance [Reproduced from Xu et al. (112)]; (B) Kaplan–Meier curves show the cumulative incidence of VOCEs (a composite of vessel-related cardiac death, vessel-related myocardial infarction, and target vessel revascularization) over 730 days of follow-up among the vessels with a low (<0.91) or high (≥0.91) post-PCI quantitative flow ratio (QFR) values in the SYNTAX II trial. (C) Black continuous line: vessels with post-PCI quantitative flow ratio (QFR) values ≤0.89. Blue dotted line: vessels with values >0.89. The cut-off of 0.89 was obtained by receiver-operating characteristic curve analysis for the best prediction of the VOCE [Reproduced from Kogame et al. (113)].