Table 1.
Comparison of various commercially available angiography-derived FFR software.
| Company | µFR | QFR | FFR angio | vFFR | caFFR | Angio-FFR | AutocathFFR |
|---|---|---|---|---|---|---|---|
| Pulse medical | Medis/Pulse Medical | CathWorks | Pie Medical | Rainmed | Siemens | Medhub Ltd | |
| Estimated | FFR | FFR | FFR | FFR | FFR | FFR | FFR |
| Required angio projections | 1 | 2 projections >25° apart | 2 projections >30° apart | 2 projections | 2 projections >30° apart | 2 projections >30° apart | 2 projections |
| Require pressure data | No | No | No | Needed | Needed | No | No |
| Side branches | Incorporated | Not incorporated | Incorporated | Not incorporated | Not incorporated | Incorporated | NA |
| Computation model | Kirkeeide | Lance Gould equation | Electric circuit model | Simplified Navier–Stokes |
Simplified Navier–Stokes |
AI based | AI based |
| Studies | Tu et al. | FAVOR pilot FAVOR II China FAVOR II EJ FAVOR III |
FAST-FFR | FAST FAST II |
FAST-FFR FLASH II |
Omori et al. | Ben-Assa E et al. (188) |
| C-statistics for predicting FFR ≤ 0.8 | 0.97 | 0.92–0.96 | 0.94 | 0.93 | 0.98 | 0.90 | 0.93 |
| Mean time to computation | 67 s | 4.36 min | 2.7 min | NA | 4.5 min | NA | 45 s |
AI, artificial intelligence; caFFR, coronary angiography-based fractional flow reserve; FAVOR, functional diagnostic accuracy of QFR in online assessment of coronary stenosis; FAST, fast assessment of stenosis severity; FFR, fractional flow reserve; µFR, Murray law-based fractional flow ratio; NA, not available; QFR, quantitative flow ratio; vFFR, vessel fractional flow reserve.