Figure 3.

NLRP3 deficiency reduces severity of pristane-induced DAH in female, but not in male mice, representative macroscopic and microscopic views of lungs. (A, B) Left column shows results with male mice (♂), right with female mice (♀). (A) Macroscopic view of the left lung lobe from PBS group and pristane-induced DAH group. (B) Representative H&E-stained section of left lung lobe from pristane-induced DAH WT and NLRP3 -/- mice. Bar 100µm. WT and NLRP3-/- mice challenged with PBS IP injection served as negative control.