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. 2024 Nov 25;15:1456150. doi: 10.3389/fimmu.2024.1456150

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Copyright © 2024 Zhang, Zhao, Lv, Wu, Liu, Chang, Yu, Xiao, He and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy evaluation of ICIs treatment and correlation analysis between CXCL12, immune cells, and inflammatory pathways. (A) Tumor immune dysfunction and exclusion algorithm indicated that high expression of CXCL12 was insensitivity to ICIs treatment. (B) CXCL12 can significantly up-regulate the expression of macrophages, monocyte cells and Tregs, and down-regulate CD8+ T cells and NK cells. (C, D) CXCL12 can significantly up-regulates inflammatory response pathway and tumor inflammation characteristic pathway.