Table 3.
Determinants of ORR.
| Characteristic | ORR | Crude OR | Adjusted | |||||
|---|---|---|---|---|---|---|---|---|
| Yes | (%) | OR | (95%CI) | p-value | OR | (95% CI) | p-value | |
| Age | 0.3441 | |||||||
| Mean (SD) | 59.30 | (10.27) | 0.97 | (0.92–1.03) | ||||
| PDL1 | 0.0025 | 0.0187 | ||||||
| Negative | 3 | (17.65) | Ref. | Ref. | ||||
| Positive | 17 | (70.83) | 11.33 | (2.46–52.15) | 8.61 | (1.72–43.0) | ||
| Unknown | 10 | (50.00) | 4.67 | (1.02–21.43) | 3.80 | (0.78–18.44) | ||
| ECOG baseline | 0.1627 | |||||||
| 1 | 22 | (57.99) | 4.12 | (0.73–23.15) | ||||
| 2 | 2 | (25.00) | Ref. | |||||
| Unknown | 6 | (40.00) | 2.00 | (0.30–13.44) | ||||
| Number of lines | 0.1058 | |||||||
| 2 | 11 | (67.71) | 2.04 | (0.63–6.64) | ||||
| 3 | 18 | (47.37) | Ref. | |||||
| >=4 | 1 | (16.67) | 0.22 | (0.02–2.09) | ||||
| Cetuximab-containing regimen | 0.0245 | 0.3146 | ||||||
| No | 15 | (38.46) | Ref. | Ref. | ||||
| Yes | 15 | (68.18) | 3.43 | (1.14–10.35) | 1.87 | (0.55–6.36) | ||
ORR, overall response rate; SD, standard deviation; OR, odds ratio; CI, confidence interval; PDL1, Programmed Death-Ligand 1; ECOG, Eastern Cooperative Oncology Group.
Mean age for non-responders is 61.47 (SD=7.81) non-significantly different from responders (ANOVA p-value = 0.3555). p-value corresponds to the log-likelihood test for comparisons between models with and without the characteristic.
Bold values indicate statistically significant values.