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. 2024 Dec 9;9:345. doi: 10.1038/s41392-024-02047-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The clusters of HER2-low MBC based on plasma ctDNA. a Clustering of HER2-low breast cancer patients using NMF. b Characteristics of the three clusters in oncogenic signaling pathways. c Mutation landscape for three molecular clusters, including cluster 1 (CS1), cluster 2 (CS2), and cluster 3 (CS3), respectively. *P < 0.05