Table 1. Summary on the applications of current persulfidation-labelling techniques.

Methods	Sensitivity	Selectivity		Feasibility		Applications
		-SSH	Targeting	Commercial availability	Prices	Samples	Techniques
Modified Biotin-switch	-	-	Specific Gloabal	✓	$	● Cell lysates ● Tissues	● Mass Spectrometry ● Immunoblotting
Cyanine5 alkyne - maleimide	-	+	Specific	✓	$	● Cell-free ● Cell lysates	● Mass Spectrometry ● Immunoblotting
Biotin-Thiol-Assay (ProPerDP; qPerS-SID)	+	+	Global	✓	$	● Cell lysates ● Tissues	● Mass Spectrometry
Low pH Quantitative Thiol Reactivity Profiling (QTRP)	++	+++	Global	✓	$$$	● Cell-free ● Cell lysates ● Tissues	● Mass Spectrometry
Tag-switch method	++	++	Global	✓	$$	● Cell-free ● Cell lysates ● Tissues	● Mass Spectrometry ● In situ fluorescence
Dimedone-switch assay	++	+++	Global	✓	$$	● Cell-free ● Cell lysates ● Tissues ● Small organisms	● Mass Spectrometry ● Confocal microscopy ● Epifluorescence deconvolution ● Immunoblotting

‘+++’ = High; ‘++’ = Medium; ‘+’ = Low; ‘-’ = not good.