Fig. 5.

(A) Amino acids (green sticks and yellow surfaces) identified as important for interaction at the active site; (B) The distances between the crucial amino acids and the most active compound 19 (cyan ball and stick); (C) The distances between the crucial amino acids and the least active compound 1 (orange ball and stick); (D) The distances between the crucial amino acids and the lower active compound 3 (pink ball and stick).