Table 3.
Treatment efficacy
| Response | ITT (n = 143) | 3L (n = 88) | ≥ 4L (n = 55) |
|---|---|---|---|
| Best response to treatment, No. (%) | |||
| CR | 0 | 0 | 0 |
| PR | 16 (11.2) | 11 (12.5) | 5 (9.1) |
| SD | 88 (61.5) | 59 (67.0) | 29 (52.7) |
| PD | 37 (25.9) | 17 (19.3) | 20 (36.4) |
| NE | 2 (1.4) | 1 (1.1) | 1 (1.8) |
| ORR, % (95% CI) | 11.2 (6.7-17.8) | 12.5 (6.7-21.7) | 9.1 (3.4-20.7) |
| DCR, % (95% CI) | 72.7 (64.5-79.7) | 79.6 (69.4-87.1) | 61.8 (47.7-74.3) |
Abbreviations: CI, Confidence interval; CR, Complete response; CT, chemotherapy; DCR, Disease control rate; ITT, Intention to treat population; NE, Not evaluable; ORR, Objective response rate; PD, Progressive disease; PR, Partial response; SD, Stable disease; 3L, third-line therapy; ≥ 4L, fourth-line and above therapy.