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. 2024 Nov 15;14(11):5154–5177. doi: 10.62347/PRFQ9244

Table 2.

Univariate and multivariate Cox analysis of LCBM characteristics

Univariate Cox analysis Multivariate Cox analysis
OS LCSS OS LCSS
HR 95% CI P Value HR 95% CI P Value HR 95% CI P Value HR 95% CI P Value
Age
    < 50 Reference Reference Reference
    50-59 1.32 1.21-1.44 *** 1.34 1.22-1.46 *** 1.21 1.11-1.33 *** 1.23 1.12-1.36 ***
    60-69 1.48 1.36-1.60 *** 1.48 1.35-1.61 *** 1.32 1.20-1.44 *** 1.32 1.21-1.45 ***
    70-79 1.89 1.74-2.06 *** 1.90 1.73-2.08 *** 1.59 1.45-1.74 *** 1.59 1.45-1.76 ***
    ≥ 80 2.38 2.15-2.63 *** 2.35 2.12-2.62 *** 1.68 1.50-1.89 *** 1.66 1.47-1.87 ***
Sex
    Female Reference Reference Reference
    Male 1.27 1.22-1.32 *** 1.27 1.22-1.32 *** 1.23 1.18-1.28 *** 1.23 1.17-1.28 ***
Race
    White Reference Reference Reference Reference
    Black 1.03 0.97-1.09 0.35 1.02 0.96-1.08 0.56 0.96 0.90-1.02 0.19 0.95 0.89-1.02 0.15
    Others 0.67 0.63-0.71 *** 0.67 0.62-0.71 *** 0.70 0.66-0.76 *** 0.70 0.65-0.76 ***
Marriage status
    Married Reference Reference Reference Reference
    Divorced/Separated 1.25 1.19-1.32 *** 1.25 1.18-1.33 *** 1.24 1.17-1.32 *** 1.25 1.17-1.33 ***
    Single 1.15 1.10-1.21 *** 1.13 1.07-1.20 *** 1.06 1.00-1.12 0.06 1.05 0.99-1.11 0.13
    Widowed 1.34 1.26-1.42 *** 1.34 1.26-1.42 *** 1.14 1.07-1.22 *** 1.15 1.07-1.24 ***
Months from diagnosis to therapy
    0 month Reference Reference Reference Reference
    ≥ 1 month 0.81 0.78-0.84 *** 0.81 0.78-0.85 *** 0.78 0.75-0.82 *** 0.78 0.75-0.82 ***
Pathological type
    Adenocarcinoma Reference Reference Reference
    Squamous cell 1.67 1.57-1.76 *** 1.67 1.58-1.78 *** 1.46 1.37-1.55 *** 1.49 1.40-1.59 ***
    Small cell 1.36 1.28-1.45 *** 1.37 1.28-1.47 *** 1.32 1.21-1.44 *** 1.34 1.22-1.47 ***
    Large cell 1.33 1.17-1.51 *** 1.34 1.17-1.53 *** 1.32 1.14-1.52 *** 1.36 1.17-1.58 ***
    Others 1.47 1.40-1.55 *** 1.42 1.34-1.50 *** 1.32 1.24-1.40 *** 1.29 1.21-1.38 ***
Grade
    Grade I Reference Reference Reference Reference
    Grade II 1.10 0.98-1.23 0.09 1.06 0.94-1.19 0.33 1.16 1.03-1.31 * 1.11 0.98-1.25 0.10
    Grade III 1.46 1.31-1.63 *** 1.40 1.25-1.57 *** 1.36 1.21-1.52 *** 1.30 1.16-1.47 ***
    Grade IV 1.57 1.39-1.78 *** 1.51 1.33-1.72 *** 1.37 1.19-1.59 *** 1.29 1.11-1.50 ***
T Stage
    T1 Reference Reference Reference Reference
    T2 1.26 1.17-1.35 *** 1.28 1.19-1.38 *** 1.29 1.20-1.40 *** 1.30 1.20-1.41 ***
    T3 1.47 1.37-1.58 *** 1.51 1.40-1.63 *** 1.43 1.33-1.55 *** 1.45 1.33-1.57 ***
    T4 1.54 1.44-1.65 *** 1.59 1.48-1.71 *** 1.45 1.34-1.57 *** 1.46 1.35-1.59 ***
N Stage
    N0 Reference Reference Reference Reference
    N1 1.06 0.98-1.14 0.14 1.06 0.98-1.15 0.12 1.06 0.98-1.14 0.18 1.07 0.98-1.16 0.13
    N2 1.20 1.14-1.26 *** 1.21 1.15-1.27 *** 1.17 1.11-1.24 *** 1.18 1.11-1.25 ***
    N3 1.22 1.15-1.29 *** 1.23 1.16-1.31 *** 1.22 1.14-1.30 *** 1.23 1.14-1.31 ***
Chemotherapy
    No/unknown Reference Reference Reference Reference
    Yes 0.36 0.34-0.37 *** 0.37 0.36-0.39 *** 0.39 0.37-0.40 *** 0.40 0.38-0.42 ***
Radiotherapy
    No/unknown Reference Reference Reference Reference
    Yes 0.59 0.56-0.61 *** 0.62 0.59-0.65 *** 0.92 0.86-0.97 ** 0.94 0.89-1.00 0.05
Surgery
    No Reference Reference Reference Reference
    Yes 0.47 0.43-0.52 *** 0.47 0.43-0.51 *** 0.55 0.50-0.60 *** 0.54 0.49-0.60 ***
Bone metastasis
    No Reference Reference Reference
    Yes 1.16 1.11-1.21 *** 1.19 1.14-1.24 *** 1.19 1.13-1.24 *** 1.21 1.15-1.27 ***
Liver metastasis
    No Reference Reference Reference Reference
    Yes 1.48 1.41-1.55 *** 1.49 1.41-1.57 *** 1.38 1.30-1.46 *** 1.37 1.29-1.46 ***
Lung metastasis
    No Reference Reference Reference Reference
    Yes 1.22 1.17-1.28 *** 1.24 1.19-1.30 *** 1.12 1.06-1.18 *** 1.14 1.08-1.20 ***

*P < 0.05, **P < 0.01, ***P < 0.001. LCBM, lung cancer brain metastases.