IC₅₀ values of compounds 1–20, determined in various human cancer cell lines (HGC-27, HT-29, HeLa, HCT-116) and normal human gastric mucosa cell line (GES-1), with 5-FU as a positive control.

Cmpd	IC50 (μM)					SI (GES-1/HGC-27)
	HGC-27	HT-29	HeLa	HCT-116	GES-1
1	8.08 ± 0.30	13.15 ± 1.29	6.23 ± 0.36	12.66 ± 1.34	18.54 ± 2.56	2.29
2	5.23 ± 0.77	6.44 ± 0.36	23.67 ± 0.58	38.46 ± 6.36	38.82 ± 26.69	7.42
3	3.96 ± 0.17	5.42 ± 0.31	7.13 ± 0.24	10.62 ± 0.28	12.09 ± 0.60	3.05
4	4.27 ± 0.15	5.01 ± 0.28	8.50 ± 0.27	12.98 ± 0.30	14.51 ± 0.72	3.40
5	4.20 ± 0.08	3.94 ± 0.20	8.81 ± 0.17	14.56 ± 0.46	10.82 ± 0.35	2.58
6	>50	>50	>50	>50	>50	—
7	5.78 ± 0.15	4.19 ± 0.21	9.71 ± 0.31	8.0 ± 0.12	9.56 ± 0.323	1.65
8	5.31 ± 0.16	3.49 ± 0.16	7.18 ± 0.22	9.21 ± 0.14	13.08 ± 0.73	2.40
9a	2.31 ± 0.25	0.91 ± 0.02	1.30 ± 0.07	4.78 ± 0.52	3.34 ± 0.16	1.44
9b	7.97 ± 0.61	5.95 ± 0.61	26.37 ± 0.72	10.94 ± 0.23	31.25 ± 10.65	3.92
10a	1.66 ± 0.29	4.67 ± 0.40	4.22 ± 0.26	3.51 ± 0.49	2.75 ± 0.31	1.66
10b	0.92 ± 0.06	1.45 ± 0.12	1.00 ± 0.06	12.43 ± 0.68	4.68 ± 1.26	5.09
11	0.96 ± 0.20	2.32 ± 0.16	1.30 ± 0.08	2.36 ± 0.46	2.34 ± 0.36	2.44
12	0.49 ± 0.04	1.64 ± 0.13	2.05 ± 0.22	2.24 ± 0.45	2.29 ± 0.48	4.67
13	0.53 ± 0.15	1.84 ± 0.10	1.76 ± 0.70	10.98 ± 0.64	2.28 ± 0.47	4.30
14	0.19 ± 0.02	0.71 ± 0.06	1.24 ± 0.10	1.03 ± 0.05	1.96 ± 0.11	10.32
15	1.20 ± 0.17	2.15 ± 0.54	2.16 ± 0.44	4.39 ± 0.69	4.65 ± 0.18	3.88
16	>50	>50	>50	>50	>50	—
17	>50	>50	>50	>50	>50	—
18	>50	>50	>50	>50	>50	—
19	1.26 ± 0.19	3.27 ± 0.95	9.91 ± 0.66	22.01 ± 4.58	41.66 ± 13.93	33.06
20	1.76 ± 0.34	3.20 ± 0.24	2.29 ± 0.14	5.79 ± 0.38	6.64 ± 0.56	3.77
5-FU	4.75 ± 0.18	4.60 ± 0.55	3.43 ± 0.33	3.32 ± 0.30	4.03 ± 0.19	0.85